There was no significant heterogeneity among the studies. When the researchers used Mendelian randomisation to combine the results of the genetic association meta-analysis with those of the gene –homocysteine association study, they found that each standard deviation increase in plasma homocysteine level was associated with a 14% increased risk of schizophrenia . Writing in Schizophrenia Bulletin, Numata and co-authors conclude that their study suggests that “increased plasma total homocysteine levels may be associated with an increased risk of developing schizophrenia”. Licensed from medwireNews with permission from Springer Healthcare Ltd. ©Springer Healthcare Ltd. All rights reserved. Neither of these parties endorse or recommend any commercial products, services, or equipment.
Elevated homocysteine not gender-specific in schizophrenia
Swedish researchers show, in two independent cohorts, that medicated patients with bipolar disorder had significantly higher serum levels of mature BDNF and a significantly higher ratio of mature BDNF to proBDNF than healthy controls. Levels of serum proBDNF were significantly lower in patients than in controls but there were no differences in serum matrix metalloproteinase (MMP)-9, which cleaves proBDNF to mature BDNF, between the groups in either cohort. Furthermore, multivariate logistic regression analyses, adjusted for gender, age and body mass index , showed that proBDNF and the matureBDNF/proBDNF ratio were significant predictors of bipolar disorder in both cohorts. Mature BDNF was only significant in one cohort (the Sahlgrenska cohort; 48 mood-stabilised patients with bipolar disorder and 43 mentally healthy controls). A statistical model that included all four serum markers discriminated between patients and controls in the Sahlgrenska cohort with a sensitivity of 89% and a specificity of 77%. In the second cohort (Karolinska; 215 mood-stabilised patients with bipolar disorder and 112 controls), the sensitivity was 74% and the specificity was 64%. When the researchers added Global Assessment of Function (GAF) scores to the model, sensitivity in the Sahlgrenska cohort increased to 100% while specificity increased to 95%.
BDNF abnormalities may predict bipolar disorder
Although data are limited and “largely circumstantial”, removal of affected teeth is often performed before cardiac surgery, including procedures other than those involving the heart valves. “We are always concerned with improving safety, and pulling teeth before heart surgery seemed to be the safer intervention,” senior author Kendra Grim said in a press statement. “We became interested in studying this complex patient group, as many patients that come to the operating room for dental surgery just before heart surgery are quite ill,” she added. The team examined the medical records of patients who underwent dental extraction before cardiac surgery at their institution over a 10-year period. A total of 208 extractions were performed and there were 206 planned cardiac operations, of which 199 were actually performed. The mean age of patients was 62 years; 80% were men. The median time between tooth removal and cardiac surgery was 7 days.
Tooth extraction before heart surgery carries risks