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You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. It is not known whether Cymbalta will harm an unborn baby. However, Cymbalta may cause problems in a newborn if you take the medicine during the third trimester of pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Cymbalta on the baby.

See also: Cymbalta pregnancy and breastfeeding warnings (in more detail)

Duloxetine can pass into breast milk and may harm a nursing baby. You should not breast-feed while taking Cymbalta.

Older adults may be more sensitive to the side effects of this medication.

Do not give Cymbalta to anyone younger than 18 years old without the advice of a doctor.

How should I take Cymbalta?

Take Cymbalta exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Try to take Cymbalta at the same time each day. Follow the directions on your prescription label.

Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include agitation, hallucinations, fever, overactive reflexes, loss of coordination, extreme drowsiness, vomiting, diarrhea, seizure (convulsions), fast heart rate, feeling light-headed, or fainting.

What should I avoid while taking Cymbalta?

Avoid drinking alcohol. *mild nausea or loss of appetite; or

*constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Cymbalta side effects (in more detail)

What other drugs will affect Cymbalta?

Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with Cymbalta may cause you to bruise or bleed easily.

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, or anxiety can add to sleepiness caused by Cymbalta. Tell your doctor if you regularly use any of these medicines, or any other antidepressant.

Tell your doctor about all other medicines you use, especially:

*a blood thinner such as warfarin (Coumadin);

*cimetidine (Tagamet);

*a diuretic (water pill);

*fluvoxamine (Luvox);

*linezolid (Zyvox);

*lithium (Lithobid, Eskalith);

*St. John's wort;

*tramadol (Ultram);

*tryptophan (sometimes called L-tryptophan);

*an antibiotic such as ciprofloxacin (Cipro);

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